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Patient Care
Innovative Pharmaceutical Solutions
Developing Targeted Solutions for Oral Comfort and Supportive Cancer Care
RAM Pharmaceuticals is advancing a patented direct-to-lesion dry-powder delivery process through two focused programs: RAMtherapeutics, an investigational supportive-oncology program, and RAMdental, a professional dental program.
Oral mucositis affects the majority of head-and-neck cancer patients receiving radiation therapy — 80% on average across 33 randomised trials, with more than half developing severe disease. There is no broadly effective pharmacologic treatment approved for it today. RAM’s delivery process is designed to put therapy directly on the lesion, and our investigational program is built to find out whether that approach helps.
RAMtherapeutics is developing Triamdocaine™, an investigational product for study in cancer therapy–induced oral mucositis. Triamdocaine™ is being developed under an active FDA IND, and RAM’s current clinical-development focus is a 90-day Proof-of-Concept study.
The burden this program is aimed at is well documented: oral mucositis occurs in 80–91% of head-and-neck radiotherapy patients, severe cases run 56–66%, and the incremental cost of managing it is roughly $5,000 to $7,000 per patient. Today providers have little to prescribe beyond supportive care.
Any subsequent Phase 2 study would be a future development step, contingent on the Proof-of-Concept results and applicable FDA review.
Triamdocaine™ is an investigational drug. It is not FDA approved, and its safety and effectiveness have not been established.
RAMdental supports licensed healthcare professionals through a patented dry-powder delivery process intended for localized intraoral application.
Acyclonine MUM™ is a 503B compounded preparation intended for professional use. It is not FDA approved, and FDA has not reviewed it for safety, effectiveness, or quality before marketing. Product selection and use are subject to the dispensing pharmacy’s current labeling and the prescribing healthcare professional’s clinical judgment.
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